A single protein can increase stem cell regeneration

A single protein can increase stem cell regeneration

Would you believe if you are told that regeneration of stem cells can be improved with a single protein? Are you wondering about the implications? This means you can recover injuries faster. Scientists funded by CIRM's Stem Cell Research Center at UCLA have confirmed that hematopoietic stem cells (HSCs), which are responsible for generating cells in the blood and immune system, act more quickly when bone progenitor cells Are injected.

Of bone progenitor cells are capable of enhancing survival and recovery of HSCs when a protein called Dickkopf-1 (DKK1) applies. This process allows for quick recovery of injuries. The study was administered in a Petri dish and in a mouse.

The main goal of the surgery was to understand how different types of cells available in bone marrow CSHs interact with in order to increase their ability to recover from an injury while improving the immune system. Lead author of the study, Professor UCLA, Dr. John Chute and his team discovered that bone stem cells in the bone marrow protein DKK1 secreted when an injury occurs. They conducted the study in mice by exposing them to radiation, causing injury.

Dr. Chute said the previous study showed that endothelial cells needed for regeneration of blood stem cells or cord when mice were exposed to irradiation. However, the last operation showed that bone progenitor cells are also necessary for the regeneration of the blood or marrow stem cell when exposed to irradiation. The study showed that Dkk1 not only improves the regeneration of HSC, but also improves the regeneration of hematopoietic stem cells. Conversely, when the Dkk1 protein has been removed from hematopoietic stem cells, stem cells do not recover or regenerate.

"The precise functions of bone cells, stromal cells and endothelial cells in regulating the fate of blood stem cells are not fully understood," he said. "Our previous studies have shown that endothelial cells are necessary for the regeneration of blood stem cells after study irradiación.El suggests that bone progenitor cells are also necessary for the regeneration of normal blood stem cells after irradiation, and that this Activity is mediated by the secretion of Dkk1 by the progenitor cells of the bone ".

Dr. Chute went on to say how his latest research on secretion of a single protein is related to CSHs his previous study on the suppression of an HSC stem cell gene to stimulate blood cell regeneration. "In this paper, we discovered the role of a protein derived from niche cells, Dkk1, and how to promote regeneration of blood stem cells after myelosuppression in mice."

Also explained: "In reporting cell reports, we describe our discovery of an adaptation protein, Grb10, which is expressed by stem or cord blood cells and whose inhibition also promotes the regeneration of stem cells Of the blood after myelosuppression. New molecular mechanisms that regulate the regeneration of blood or marrow stem cells could be therapeutically directed ".

We can conclude that both investigations have contributed greatly in the treatment of patients who need a boost in their blood and followed by radiotherapy or bone marrow transplant immune system.